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It was unexpected when on the morning of November 24, 2013 Iranian chief negotiator Jawad Zarief tweeted that we have reached an agreement. Soon after his tweet the news spread out to the world observers, analysts and international community welcomed the deal but interestingly the countries from Middle East showed some mix reaction on this agreement which could become an important factor for the future deal between Iran and P5+1. This article is based on an analytical study to understand the causes behind the regional concerns on Iran's nuclear policy and also to identify the effects of recent agreement between world powers and Tehran on the politics of the region. It also tries to examine and evaluate the futuristic approach of important regional players on the issue of nuclear Iran.