Survey on Major Micro Vascular Complication of Diabetes Mellitus Type 1(T1DM) Patients in Different Age Groups in Hyderabad and Jamshoro

  • Tahira Jabeen Ursani
  • Fahmida Channa
  • Abdul Rasool Abasi
  • Jawaid A. Khokhar
  • Samina Malik
Keywords: Diabetes; age group, hyperglycemia; Micro vascular Complications; Neuropathy; Nephropathy;Proteinuria; Microalbuminoria ;Urinary incontinence.


Diabetes mellitus is a common medical condition known to have adverse effects on all system of human body.Diabetes mellitus (DM) is becoming a major threat to global public health. There were 382 million people who suffered from DM worldwide in 2013. Diabetes mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemia resulting from defects in insufficient insulin secretion, insulin action, or both.  The type 1 diabetes mellitus (T1DM) is a multifactorial autoimmune disease which susceptibility is determined by a combination of genetic and environmental factors. Microvascular complications are specific to diabetes and related to longstanding hyperglycaemia. Both Type 1 DM and Type 2 DM are susceptible to microvascular complication. The risk of developing diabetic retinopathy or other micro vascular complications of diabetes depends on both the duration and the severity of hyperglycemia. The aim of this study was to evaluate the frequency major microvascular complication of different age group patients with diabetes mellitus type 1(T1DM) and was conducted in medical outdoor patient (OPD) of two main hospitals named as Civil Hospital Hyderabad and LUMHS Hospital Jamshoro from  july 2018 –december 2018. Out of 410 T1DM patients 250 (61%) were males and 160 (39%) were females were enrolled in the present study. The present study concluded that total 410 Diabetic patients have major microvascular complications included 180 (44%) DR patients, 125 (30.4%) nephropathy patients and 105(25.6%) diabetic neuropathy patients .Out of 180 patient 120( 66.66%)males have DR and 60 (33.33%) females were DR.Out of 125 diabetic nephropathy patients  70 males(56%) were suffer and 55(44%) females. Out of 105 diabetic neuropathic patients 60(57%) males and 45 (43%) females. Out of 180 DR patients 117(65%) patients have NPDR & 63(35%) have PDR.Out of 125 DN patients 110 patients have proteinuria , 90 paients have swelling of hands ,feet & ankel , 95patients have swelling on eyes & 80 patients have confusion or difficulty to concentrate on work Out of 125 DN patients 100(80%) patients have microalbuminoria and 25(20%) patients have end  stage renal failure(ESRD) .Out of 105 Diabetic neuropathy patients 100 have numbness , 95 have muscles weakness,90 have constipation sometimes diarrhoa ,65 have urinary incontinence.