BPA.BPS Histological Comparison of Splenic Hemosiderosis Toxic Effect of Bisphenol A (BPA) and Bisphenol S (BPS) in Mus Musculus

Abstract

Bisphenol A (BPA) and Bisphenol S (BPS) are phenolic organic compounds. These compounds are commonly used in the manufacturing of plastic containers, epoxy resins, food and drink cans, water pipes, electronic equipment, thermal paper, kitchen utensils, toys, and dental sealants. The general population exposed to bisphenol S, both directly (through oral and/or topical routes) and indirectly (through environmental pollution and/or food chain).? The main objective of the study was to evaluate the effect of Bipshenol A and Bisphenol S on the spleen of mice. Mice were equally divided into three groups, i.e., Control group (given water only), and dose group II (orally administrated 40mg/kg body weight, Bisphenol A for the period of 21 days) and dose group III (orally administrated 40mg/kg body weight, Bipshenol S for the period of 21 days) after dissection the spleen of the all mice were extracted and further processed for morphological, morphometric and histological analysis. The Bisphenol A treated group of mice shown that an evident (p<0.001) increased in the body weight and the spleen weight of the Bipshenol A treated dose II treated group as compared to the control group, where significant (p<0.001) decreased in the body and spleen weight were observed in the dose group III bisphenol S in comparison of with the mice of dose group II Bisphenol A. Histological analysis of dose group II Bisphenol A showed some abnormalities in the Spleen of mice like parenchymatic cells with an increased number of megakaryocytes, vacuolated cytoplasm, and irregular nuclei, thickening in the capsule, destruction of marginal zone red pulp and destruction in the white pulp. It concluded that the excessive and long-term use of Bisphenol A and Bisphenol S leads to impaired vital organs of albino mice, causing the impairment in blood parameters and splenic toxicity. This plastic product must be used with care, particularly for products underuse by children.