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COVID-19 seems to be one of the most dangerous pandemics which originated from Wuhan, China, and spread all over the globe. There are several studies which are covering various aspects of COVID-19 although one that may aid in the understanding of major predictors for the outbreak is massively important. Therefore, this study has been conducted to identify the perception and understanding of the population of Karachi. The study follows public opinion not just because of the unavailability of data & the major reason for the use of public opinion is to gauge the severity of different predictors according to the inhabitants of Pakistan. The data has been collected through a self-developed questionnaire which is based on the indication of WHO and research work on pandemics. These indications were linked to the Likert scale & analysis was incorporated through SMART-PLS which indicated that contact transmission and droplet transmission are the major predictors of COVID-19.