Study of some Hematological parameters as Biomarker for breast Cancer population of Sindh

Abstract

Cancer is the second largest killer worldwide, Breast cancer is one of the most widespread diseases affecting women. The prevalence of breast cancer is increasing gradually in developing countries. Especially, Pakistani women are more victims of breast cancer among the Asian population. The incidence of breast cancer in the Pakistani population is 2.5 times higher than in the neighboring nation. There are various factors which play a role in the development of breast cancer, majorly are environmental andgenetical. The aim of present study was to analysis the association and variation in hematological parameters of breast cancer patients.The study was conducted at Medical Research Centre, Liaquat University of Medical & Health Sciences, Jamshoro. In this study 80 breast cancer patients were selected for hematological parameters. The patients mostly involved in this study were above 40 years. The questionnaire used in this study designed was to know the age, marital status, duration of the disease, diet habits, physical exercise, and duration of feeding, family history and mode of treatment. Blood samples were collected from the participating members of the breast cancer patients after an informed consent was signed.The incidence of breast cancer was found high at the age above than 40 years woman and less than 60 years. The peak age group for the occurrence of breast cancer in Sindh`s females was 45-55 years. Breast cancer was not found in underweight the women. Number of WBC and RBC decreased in the cancer patients than the normal range. Our study suggested that the BMI, ESR, and Hematological parameters especially Lymphocyte and Neutrophils are as important tools for diagnosis of stage and monitoring of breast cancer.