Drug Imprinted Solid Phase Extraction of Ciprpfloxacin from Aqueous Solutions

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M. M. GAHO
G. Z. MEMON
J. R. MEMON
N. N. MEMON
M. Q. SAMEJO
M. S. QURESHI

Abstract

During the study of antibiotics of molecularly imprinted polymers (MIPs) using non covalent molecular imprinting technique, MIPs were synthesized for the exclusion of selected antibiotics from the aqueous solutions. For this purpose, polymerization of ciprofloxacin as a template was performed using Methacrylic acid (MAA) as monomer, (EGDMA) Ethyleneglycodimethacrylate cross-linker, the (AIBN) 2,2-azobisisobutyronitrile as an initiator and toluene as porogenic solvent. The template Ciprofloxacin was removed by leaching with 0.1 M HCl. The MIP particles were characterized by Infra-red spectroscopy and (SEM) scanning electron microscopy. The adsorption parameters i.e. pH, shaking time, doze optimization, effect of temperature and concentration have been studied. The optimized dozewascalculatedtobe0.005gm.,optimizedshakingtime30min,andatpH6maximum % adsorption was observed. The D-R models, Freundlich and Langmuir were applied to study the multilayer adsorption capacity, monolayer capacity of adsorption and mechanism of the adsorption. 1st order rate constant (k) and Rd (intra particle diffusion constant) have been calculated by using kinetics models. In thermodynamic studies, ΔG & ΔS, ΔH have been calculated.

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