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The study was conducted in Balochistan Institute of Nephro-Urology Quetta (BINUQ). One hundred (n=100) subjects were included amongst fifty were hypertensive and fifty were normal healthy. Demographic data was collected by questionnaire from all the participants. Venous blood samples were collected to analyze serum creatinine and uric acid by using semi-automated analyzer and estimated Glomerular Filtration rate (eFGR) was calculated by using Modification of Diet in Renal Disease (MDRD) study estimating equation. SPSS was used for statistical analysis. The data shows that levels of serum creatinine and serum uric acid was found significantly high in hypertensive patients as compared to normal subjects (P=0.00). During study different risk factors like age, Body Mass Index (BMI), diabetes, smoking, alcohol consumption, exercise, occupation, salt intake were also analyzed in both normotensive and hypertensive patients. It was found a strong association of these risk factors with high blood pressure (P=0.00). A significant association of creatinine, eFGR and uric acid is found with hypertension and Choronic kidney disease (CKD). It was also found that due to increased creatinine count, 46% hypertensive patients have kidney disease(P=0.00). The individuals with normal levels of BP have normal level of creatinine. So it is concluded that Creatinine, eFGR and Uric acid are the important bio chemical markers to identify the kidneys dysfunction in hypertensive patients.