Anti-Diabetic Impact of Momordica Charantia Seed and Aloe Barbadensis Miller Gel Powder in Sprague Dawley Rats

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Makkia Saleem
Roma Saleem
Mian Kamran Sharif


Diabetes mellitus is the 4th leading cause of death worldwide. Diet-based approaches to treating various health disorders are considered safe, economical, and sustainable. Complementary and alternative medicine (CAM) is one of the methods used worldwide for the management of diabetes millets. The present study was designed to achieve the following objectives: to analyze bitter melon seed (BMS) and aloe vera gel (AVG) powder for proximate and mineral content; to develop functional chicken nuggets by using various concentrations of both powdered and their compositional analyses and to probe the antidiabetic potential of powders in synergy. A control and two formulations were selected, based on consumer acceptability, for efficacy trial through the animal model of 30 days. For this purpose, 18 diabetic Sprague Dawley Rats were randomly divided into 3 groups. The groups included the positive control group (G0, normal diet) and two other groups with different AVG and BMS powder. G1 group received 50% BMS and 50% AVG powder whereas, G2 was fed on 75% BMS and 25% AVG powder per day. G1 showed a significant reduction in fasting blood glucose level, glycated hemoglobin, cholesterol, LDL-Cholesterol, blood urea nitrogen, and uric acid, whereas the G2 showed improvement in insulin, HDL-Cholesterol, and triglycerides levels whereas showed better control over time. Supplementation of BMS and AVG can help to control hyperglycemia and related complications.

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Makkia Saleem, Roma Saleem, & Mian Kamran Sharif. (2022). Anti-Diabetic Impact of Momordica Charantia Seed and Aloe Barbadensis Miller Gel Powder in Sprague Dawley Rats. Sindh University Research Journal - SURJ (Science Series), 54(1).


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