Irrational Use of H1 Receptor Antagonist In Various Allergic Patients, A Clinical Study in Hyderabad, Sindh

Abstract

The objectives of current study were to quantify the number of allergic patients utilizing H1 receptor antagonist with proper
dose in allergic patients and to observe any side effects produced due to intake of H1 anti-histamine.
A descriptive cross sectional study was conducted by collecting the patient’s data on predesigned questionnaire. A total of 200 patients
were enrolled via purposive sampling from out-door patients tertiary care hospitals of Hyderabad, Sindh for a period of 06 months.
Out of total 200 patients male was 68.5% and female was 31.5%). Maximum number of patients was from the age group between 16 – 30
years. Patients having flu were more in number of 34%, 31% were of common cold, 21% of skin rash & 12% were of cough. 37%.
Loratidine was commonly used in patients which is 2nd generation H1 receptor antagonist (anti-histamine). 48% patients were taking BD
dose, 41% of OD & 11% patients were taking TDS. Through the survey & pre-designed questionnaire, it was found that most of the
patients were taking anti-histamine without the prescription of doctor as all anti-histamines are easily available in all pharmacies and the
patients were experiencing side effects because of no dose adjustment by doctor or a pharmacist. 67% patients were experiencing Dry
nose, 51% headache, 45% of dry mouth and drowsiness each, 42% were feeling sickness.
By initial studies it was concluded that patients are using H1 Receptor antagonists because of easy availability of drugs in our
pharmacies. Study analysis also shows that patient taking anti-histamine for longer period of time due to lack of awareness. Frequently
usage of anti histamine can cause drug dependence as well as adverse drug reactions