Frequency of ADRs among Monotherapy and Combinations therapy Hypertensive Patients from Private Tertiary Care Hospital of Hyderabad, Pakistan

Abstract

The objective of current study was to evaluate the frequency of adverse drug reactions (ADRs) among monotherapy and combinations therapy patients who had confirmed Hypertension from private tertiary care hospital of Hyderabad, Sindh, Pakistan. Methodology: A qualitative based study was explained descriptively and sample was taken on the basis of purposive technique, a total of 940 hypertensive patients were taken from the out-door patients who were taken atleast one antihypertensive medication. The duration of study was 2 years. The questionnaire were designed with the help of experts on the basis of study aims i.e. to evaluate the frequency of ADRs. Results: Out of 940 patients, 53.94% were belonged to male gender i.e. maximum, 76.91% were living in urban areas. Maximum patients were recruited from cardiac out-patient department i.e. 57.87%. The maximum age of enrolled patients was between 49 to 58 years i.e. 37.13%. 61.06% were on various antihypertensive combinations therapy. Among monotherapy Telmisartan was the most common prescribing drug and among dual therapy the most common was Valsartan+Amlodipine. Among triple therapy enalapril+hydrochlorothiazide+Atenolol was the most common prescribing medicines. Out of total patients, 17.49% ADRs were among monotherapy, 16.44 were among dual therapy, 20.74% were among triple therapy and 19.12% were among quadruple therapy patients. Conclusion: It was concluded that maximum ADRs were due to combination therapy so the data reflects clearly that proper guidelines should be follow while prescribing the antihypertensive medications so the prevalence of ADRs will be reduced.