Physiological effects of Cinnamomum cassia bark extract on β-cells of Islets of Langerhans in alloxan induced diabetic rats

Abstract

Cinnamomum cassia (C. cassia) is a culinary spicy herb. Use of C. cassia for blood glucose regulation has been known since ancient days. The study was conducted to investigate effects of Cinnamomum cassia bark extract (CCBE) & Sitagliptin on β-cell of islets of Langerhas as evaluated by serum insulin and blood glucose. 30 Albino rats of either sex were studied. Blood samples were collected, stored and processed in postgraduate laboratory. Data was analyzed on SPSS version 21.0. (IBM, corporation, USA). P-value of significance was defined at ≤0.05. The C. cassia bark extract showed blood glucose lowering and insulin releasing effects comparable to sitagliptin. The effect was observed at both low and high doses of C.cassia. It is concluded that the C. cassia bark extract regulates blood glucose homeostasis and enhances insulin secretion from β-cells of islets of Langerhans.