INVESTIGATION OF CREATINE PHOSPHOKINASE (CPK) LEVEL IN BLOOD SERUM OF MALARIAL PATIENTS

Abstract

Malaria is the most common infectious disease causes millions of deaths worldwide and it is a major public health problem in Pakistan. In the present study blood serum levels of creatine phosphokinase (CPK) was determined in 12 malarial patients and 12 healthy control subjects by using kit method on Microlab 300. The results obtained for malarial patients were compared with those obtained for the healthy subjects. Enzyme CPK is most abundant in heart, skeletal and brain muscles and in small quantities in tissues such as smooth muscles. It has been observed that in malarial patients the mean levels of CPK significantly decreases as compared to that determined in healthy subjects. The mean value of CPK determined to be 77 with the standard deviation of 38.8072 for 12 malarial patients as compared to 12 normal subjects with the mean value of 86.34 and standard deviation of 33.82396.