AI-Powered Genetic Algorithm-Based System for Predicting Diabetics Risk in Future Generations
DOI:
https://doi.org/10.26692/surjss.v57i1.7561Keywords:
Diabetes, Mendalian Genetics, type 2 diabetes, artificial intelligence, machine learningAbstract
Diabetes is a global health concern leading to complications such as high blood pressure, kidney failure, and vision impairment. Effective management of diabetes involves maintaining a healthy lifestyle with proper diet and exercise. This research focuses on predicting the transmission of diabetes to future generations using classical Mendelian genetics combined with a probabilistic model enhanced by Artificial Intelligence (AI) and machine learning (ML). Real-time data was collected from endocrinologist associated with various families maintaining the ethical privacy of their datasets. The study employs Mendelian laws of genetics to analyze the inheritance patterns of diabetes focusing on dominant and recessive alleles. Integrating Mendelian genetics with probabilistic rules (Naïve Bayes), the methodology offers a robust framework for predicting diabetes transmission. The findings highlight significant generational differences, revealing that diabetic parents have a strong likelihood in a sample of 400 individuals of passing diabetes to their offspring. This intelligent application allows individuals without technical or biomedical knowledge to easily predict the risk of diabetes in their next generation. This application validated through Mendelian laws and probabilistic models using AI and ML, holds promise for future expansion to address related diseases like kidney failure, eye problems, high blood pressure, and heart disease. By making this tool accessible to a lay audience, it enhances understanding of diabetes inheritance and offers a powerful resource for genetic prediction.
References
Admin. (2023, January 5). Mendel’s Laws of Inheritance - Mendel’s Laws and Experiments. BYJUS. https://byjus.com/biology/mendel-laws-of-inheritance/
Bateson, W., & Mendel, G. (2013). Mendel's principles of heredity. Courier Corporation.
Berrar, D. (2019). Bayes' theorem and naive Bayes classifier.
Birjais, R., Mourya, A. K., Chauhan, R., & Kaur, H. (2019). Prediction and diagnosis of future diabetes risk: a machine learning approach. SN Applied Sciences, 1, 1-8.
Davis, L. C. (1993). Origin of the Punnett square. The American Biology Teacher, 55(4), 209-212.
Edwards, A. W. F. (2012). Punnett’s square. Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences, 43(1), 219-224.
Gautier, T., Ziegler, L. B., Gerber, M. S., Campos-Náñez, E., & Patek, S. D. (2021). Artificial intelligence and diabetes technology: a review. Metabolism, 124, 154872
Genetics, autosomal dominant. (2024, January 1). PubMed.
Germain, D. P., & Jurca-Simina, I. E. (2018). Principles of human genetics and Mendelian inheritance. Neurometabolic hereditary diseases of adults, 1-28.
International Diabetes Federation. (2023, June 7). Pakistan - International Diabetes Federation.
Kavakiotis, I., Tsave, O., Salifoglou, A., Maglaveras, N., Vlahavas, I., & Chouvarda, I. (2017). Machine learning and data mining methods in diabetes research. Computational and structural biotechnology journal, 15, 104-116.
Mujumdar, A., & Vaidehi, V. (2019). Diabetes prediction using machine learning algorithms. Procedia Computer Science, 165, 292-299.
Müller-Wille, S., & Parolini, G. (2020). Punnett squares and hybrid crosses: how Mendelians learned their trade by the book. BJHS Themes, 5, 149–165.
Pakistan diabetes report 2000 — 2045. (n.d.). International Diabetes Federation.
Prasad, R. B., & Groop, L. (2015). Genetics of type 2 diabetes—pitfalls and possibilities. Genes, 6(1), 87-123.
Priya, K. L., Kypa, M. S. C. R., Reddy, M. M. S., & Reddy, G. R. M. (2020, June). A novel approach to predict diabetes by using Naive Bayes classifier. In 2020 4th International Conference on Trends in Electronics and Informatics (ICOEI)(48184) (pp. 603-607). IEEE.
Rossi, A., & Kontarakis, Z. (2022). Beyond Mendelian inheritance: Genetic buffering and phenotype variability. Phenomics, 2(2), 79-87.
Sebastiani, P., Solovieff, N., & Sun, J. X. (2012). Naïve Bayesian classifier and genetic risk score for genetic risk prediction of a categorical trait: not so different after all!. Frontiers in genetics, 3, 26.
Sisodia, D., & Sisodia, D. S. (2018). Prediction of diabetes using classification algorithms. Procedia computer science, 132, 1578-1585.
Tapak, L., Mahjub, H., Hamidi, O., & Poorolajal, J. (2013). Real-data comparison of data mining methods in prediction of diabetes in Iran. Healthcare informatics research, 19(3), 177-185.
World Health Organization: WHO & World Health Organization: WHO. (2023, April 5). Diabetes.
Xu, S. (2022). Review of Mendelian Genetics. In Quantitative Genetics (pp. 13-24). Cham: Springer International Publishing.
Yu, W., Liu, T., Valdez, R., Gwinn, M., & Khoury, M. J. (2010). Application of support vector machine modeling for prediction of common diseases: the case of diabetes and pre-diabetes. BMC medical informatics and decision making, 10, 1-7.
Yule, G. U. (1902). Mendel's laws and their probable relations to intra-racial heredity (continued). New Phytologist, 1(10), 222-238.
Zschocke, J., Byers, P. H., & Wilkie, A. O. (2023). Mendelian inheritance revisited: dominance and recessiveness in medical genetics. Nature Reviews Genetics, 24(7), 442-463.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Sindh University Research Journal - SURJ (Science Series)

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.


