DIRECT DETERMINATION OF SOME ADRENERGIC DRUGS BY THERMOMETRIC TITRIMETRY USING N-BROMOSUCCINIMIDE

Abstract

A rapid and specific method for the determination of ephedrine HCI, norephedrine HCI, adrenaline and isopropylnoradrenaline in pure and in the presence of excipients is reported. The method is based on the oxidation reaction with N-bromosuccinimide in the acidic medium. The heat of reaction is used to determine the end point of the titration. The validity of the method was tested by comparing to those results obtained by official procedures. The accuracy and precision is analytically acceptable and the time required is less than five minutes.