COMPARATIVE DISSOLUTION RATE STUDIES ON NON NARCOTIC ANALGESICS

Abstract

Five different brands of these non-narcotic analgesics, prepared by local pharmaceutical industries i.e. Paracetamol, Mefenamic acid and Ibuprofen have been examined for their dissolution and disintegration rates in vitro. The different brands of each product exhibited significant difference in dissolution rate. These differences probably account for some of the conflicting clinical reports concerning the bioavailability of various tablets of Paracetamol, Mefenamic acid and Ibuprofen sold under different names. These tablets were tested for all their physical parameters in addition to assay, disintegration and dissolution rates. Thus a comparative study on disintegration and dissolution rates of five brands of three different non-narcotic analgesic was made to assess the quality of the tablets, manufactured by pharmaceutical companies.