Antibacterial Activity of Polyoxometalates (POMS) Against Urinary Tract Infection (UTI) Causing Bacteria

Abstract

Present study deals with the antimicrobial and antioxidant activities of polyoxometalates (Silicovanadate and Iron substituted Phosphotungstate) and their synergistic effect with beta lactam antibiotics against urinary tract infection causing bacteria. Three beta lactam antibiotics resistant strains such as E. coli, P. aeruginosa and K. pneumoniae are more prominent to cause urinary tract infections. Serial dilutions were prepared with concentration ranging from 5 to 15 μg/ml.MIC of both POMs was 5μg/ml concentration against all three strains and measured by scaling. The antioxidant activity of POMs was measured by spectrophotometer for different concentrations and compared with ascorbic acid used as standard. Antibacterial as well as antioxidant activity of silicovanadate was observed more than that of ironosubstituted phosphotundstate and increased as we increased the concentrations of both compounds.