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The adoption of Information Technology (IT) has remained a point of enthusiasm for the last couple of decades. The Technology Acceptance Models such as TAM are used to predict users’ behaviours. Studies on the ability to anticipate people's acceptance with regard to health information system (HIS) are lacking. This study focuses on the “Perceived Ease of USE (PEOU)” and the “Perceived Usefulness (PU)” of the HIS of healthcare professionals in Pakistan. The first step is to examine the level of acceptance and then the willingness to upgrade the HIS for the betterment of the healthcare services in Pakistan among the stakeholders. Consequently, this study used model and proposed that the HIS acceptance is determined by 5 main constructs, namely, “behavioural intention”, “attitude, perceived usefulness”, “perceived ease of use” and “technology self-efficacy”. In this model, “Technology Self-Efficacy (TSE)” had positive and significant effect on “perceived usefulness (PU)” and “Perceived ease of use (PEOU)”. “PEOU” has both positive and significant effects on “perceived usefulness (PU)” and attitude. “PU” had positive significant effect on “attitude” and “behavioural intention”. “Attitude “had positive and significant effect on “behavioural intention”. A questionnaire was designed based on the conceptual model. A seven-factor Likert scale became used during the questionnaire. A survey was then performed after pre-testing the statistics collecting device. valid responses have been coded and analyzed by means of the usage of the Statistical package for the Social Sciences (SPSS) model 21. each descriptive and inferential analyses had been done. The developed version become tested on a pattern of 200 health care specialists of Pakistan.
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