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The region of South Asia is vulnerable due to nuclear powers of India and Pakistan. Former launched its program in reaction to China whereas latter followed the suit in Indian reaction. Pakistan undertook atomic explosion as India again tested its nuclear devices in May 1998. The atomic explosions in the region paved the way for international reaction. Japan being first and last victim of nuclear weapons also came forward and made efforts to restrain Pakistan from following action of India. After explosion by Pakistan, international community including Japan condemned nuclear race in South Asia. Pakistan had to face Japanese reaction at various levels. It seems that Japan is also not satisfied with justification of Pakistan regarding Pakistan-North Korea nuclear cooperation. However nuclear proliferation is not restricted only to Pakistan.