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South Asia possesses unique position in the arena of international state affairs. There are two nuclear states; Highly skilled manpower, abundance of natural resources; strategic importance of Indian Ocean, Central Asian States and security matters make South Asian region very important in international politics. China gives much importance to South Asia in its diplomatic and foreign policy relations. As India wants to create its hegemony in South Asia so China tries its level best to confront Indian hegemony. This paper explains that how China and Pakistan have developed friendly relationship to contain Indian dominance in the region. It has balanced the power (military and economic) and Indian threat has also been minimized. This paper also examines the role of other major powers especially USA and Russia towards Pakistan and India briefly.